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Angelman Syndrome is caused by an abnormal function of the UBE3A gene, located in a small region on (q11-q13) on Chromosone 15. Can be caused by deletion, uniparental disomy, imprinting center defect, or UBE3A protein abnormality. Some traits is AS is a happy demeanor, unsteady gait, movement disorders, developmental delay, feeding problems, sleeping problems, little to no speech, Hypopigmentation, seizures, Strabismus, and hyperactivity. Angelman people have a wide range of capabilites. Some need assistance feeding, dressing, and with all daily living activites. Some are mostly self sufficient for intstance can feed, dress, and some even have a range of vocabulary, but no one to date that has been found can have converstaional speech, or live alone.
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