Sixty percent to 70 percent of people with ADPKD have cysts in the liver during their lifetime. Liver cysts rarely occur in those under the age of 30 but do form and increase as a person ages. Even though there is an increase in liver size, the amount of functional liver tissue remains fairly constant. Liver cysts occur as often in men as in women. However, women have liver cysts at a younger age than men. Women also have more and larger cysts than men. Women who have been pregnant are more likely to have liver cysts; and the cysts are more numerous and larger in women who have been pregnant compared to women who have not been pregnant.

Mitral valve prolapse (MVP) is a condition where the valve separating the top and the bottom of the left side of the heart does not close properly. Sometimes this causes blood to leak back to the top part of the heart. This is called regurgitation and can be heard during an examination of the heart as a heart murmur. MVP occurs in approximately 26 percent of the people who have ADPKD compared to 2 percent to 3 percent of the general population. Symptoms that can be associated with MVP are palpitations, a feeling that the heart is running away or that there are extra beats in the heart, and chest pain that is not associated with exercise or exertion.

People with ADPKD have about a 5 percent to 10 percent risk of developing intracranial aneurysms. These aneurysms seem to cluster in certain families. That is, if a member of your family has an aneurysm or has ruptured an aneurysm, you may be at a higher risk of having an aneurysm also. People who have ADPKD and a family history of aneurysm should be tested. An aneurysm is an outpouching in a blood vessel. 

Both inguinal and umbilical hernias are more common in those with ADPKD. Inguinal hernias are outpouchings in the area of the groin and umbilical hernias are outpouchings at or near the navel.

Diverticula are outpouchings on the large intestine (colon). It seems that people with ADPKD who are on dialysis or have had a transplant have diverticula more often and more complications from diverticula, including infection, than people who have other kidney diseases.