On Mystery Diagnosis 2-11-08

& had rare: Cold agglutinin

 

cold outside

 

Had no feeling & cold senstion in parts of his body;

hands and feet had purple blotches

Second opinion doctor said his spleen was 10 times larger than normal,

said he had a low grade lymphoma that had not reached the lymph nodes, so not found previously

 

AIHA Autoimmune hemolytic anemia. Occurs when the body produces antibodies that coat red blood cells.	In autoimmune hemolytic anemia, the body produces autoantibodies to red blood cell membrane proteins. (size? shape RBCs?)  The FATIGUE???    Help?   Diagnosis help  The basics
Immune System Activated Coagulopathy	Thickening of the blood caused by Immune System
Cold Agglutinin	Cold agglutinin disease is an acquired autoimmune hemolytic anemia due to an IgM autoantibody usually directed against the I antigen on red blood cells.
Porphyria?	Porphyria is a metabolic problem that is thought to be hereditary; however, it could be chemically induced.  Difficulty in making heme, which is the primary component of hemoglobin in red blood cells. Their lab tests reveal abnormal activity in one or more of the eight enzymes involved in heme production. Since most heme is made in the bone marrow, these "disorders of porphyrin metabolism" are usually found there or in the liver.