The next study from Australia looks at erythrocyte (RBC) damage ie shape of cells....this harkens back to DR Simpson's tests...many gulf war vets had sent blood to him to be examined early on. I was one of those and yes the red blood cells were distorted in shape. Not only that but the first thing I noticed after returning from the gulf war was that my RBC count which had never had problems re annual physical being a flight nurse and even after moving to Denver (higher altitude) I never had any change until the gulf war. My RBS had dropped to a borderline level. This shift definitely had me the old nurse look twice and say wow what happenned!
I am wondering how many other gulf war vets had a shift in the number of red blood cells and also how many had the RBC shape evaluated by Dr Simpson?
Seems to me we should contact him and ask him to summarize his findings on the gulf war vets he tested.
The results: There was evidence of oxidative damage in CFS with statistically significant increases in 2,3-DPG (p <0.05), metHb (p <0.005) and MDA (p <0.01). The CFS patients in this study also had significantly more stomatocytes
Again this could be termed a diagnostic test! Again what would be the cost factor per vet? What would be the ability of the VA to implement testing for 2,3 DPG, metHb, and MDA?
I am asking questions and hoping someone at the VA can answer these questions for me!
Again I would think it would not be that hard to add this as a diagnostic test to be done on gulf war vets . How much research is needed to move some of these tests into reality as diagnostic testing?
Erythrocyte oxidative damage in chronic fatigue syndrome.
School of Community Health, Faculty of Health Sciences, Charles Sturt University, NSW, Australia.
BACKGROUND: It has been hypothesized that a link exists between erythrocyte metabolism (particularly redox metabolism) and erythrocyte shape and that both are related to erythrocyte deformability. The aim of this research is to confirm the results of earlier studies and to investigate a correlation between erythrocyte morphology and erythrocyte oxidative damage in chronic fatigue syndrome (CFS). METHODS: Reduced glutathione (GSH), malondialdehyde (MDA), methemoglobin (metHb) and 2,3-diphosphoglycer ic acid (2,3-DPG) were measured in 31 patients suffering from CFS and 41 healthy control subjects. Scanning electron microscopic studies of the erythrocytes from both groups were also carried out. RESULTS: There was evidence of oxidative damage in CFS with statistically significant increases in 2,3-DPG (p <0.05), metHb (p <0.005) and MDA (p <0.01). The CFS patients in this study also had significantly more stomatocytes in their blood than the normal subjects (p <0.005). CONCLUSIONS: There is a strong likelihood that the increase in erythrocyte antioxidant activity is associated with the presence of stomatocytes. The results of this study provide further evidence for the role of free radicals in the pathogenesis of CFS and a link between erythrocyte metabolism and erythrocyte shape.
PMID: 17174731 [PubMed - in process]
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This is also what is noticed by those with known exposure to 2-butoxyethanol .... fragility of RBC membranes .... and borderline normal range. I believe this is why doctors do not find THE FATIGUE (per definintion of CFS, FM, CFIDS) which with this chemical exposure would be compensated autoimmune hemolytic anemia. Doctors must LOOK at the red blood cells
The harm of 2-butoxyethanol is unrecognized!
Central Nervous System Effects:
Difficulty Concentrating
Short Term Memory Loss
Difficulty Sleeping
Constantly Irritable
Depression
Suicidal Tendencies
Horrible Headaches
Do you recall any times of severe flu-like symptoms more and Horrible FATIGUE? AIHA Fatigue clues:
Chills
Fatigue
Pale color
Shortness of breath
Rapid heart rate * *
Yellow skin color (jaundice)
Dark urine
Enlarged spleen
Eyes burning & hurting
Red blood cells immature? etc
Blood in Urine?
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Is CFIDS fatigue - compensated autoimmune hemolytic anemia?
Some basic things to check - to find THIS fatigue
Janitorial Studies on EGBE & its complex form
What Can 2-butoxyethanol Cause?
Hematology Overview Alternate chart with more details
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- Present an abnormal blood picture showing: Erythropenia
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- Present an abnormal blood picture showing: Reticulocytosis
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- Present an abnormal blood picture showing: Granulocytosis
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- Present an abnormal blood picture showing: Leukocytosis
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- Likely to Cause Fragility of Erythrocytes
| Are red blood cells small sized? |
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- Causes Central Nervous System (CNS) DEPRESSION
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A flight nurse, addendant can get the chemical exposure second hand, as those strongly exposed can expel it in their respiration (MY theory) I believe my husband had similar last week sitting across from someone on a plane
http://groups.msn.com/valdezrentals/drunkcrazyman.msnw
I recognize 'the pattern' of this particular chemical exposure, that's all CFIDS, CFS, FM Those who go to the doctor are generally told there is nothing wrong with them. If I'm right, he would have had an elevated 'retic rate' just at 2.5 days after serious exposure (So at noon on Friday) * Compensated autoimmune hemolytic anemia * Can Dr Reg Crack the Case ?
"A reticulocyte count is a blood test that measures how rapidly immature red blood cells called reticulocytes are made by the bone marrow and then released into the bloodstream. Reticulocytes circulate in the bloodstream for about 2 days before developing into mature red blood cells. Normally, about 1% to 2% of the red blood cells in the bloodstream are reticulocytes"
Look for THIS fatigue *
"The presence of spherocytes indicates that red blood cells are being destroyed."
very sick
