ALD results when mom has damaged X chromosome

Lorenzo's Oil was a touching documentary  Lorenzo now ald Adrenoleukodystrophy (ALD) Could a girl be affected prior to her birth if one or both parents had serious exposure to 2-butoxyethanol?  Or could she be affected by her own exposures throughout her life?  Then could she have what would cause ALD in her child? ALD is said to be genetic - on a mom's X chromosome  * The Myelin Project:  Hope for Multiple Sclerosis, the Leukodystrophies, and other Myelin Disorders  ... but are there some similarities?  I noticed in the film that they had a trial study of immune suppression, which leads me to believe that the immune system was noticed as being 'over active'  I would suspect autoimmune. When Lorenzo's dad noticed that the Polish rat study, and the camera panned on what he found of interest, there was another word, such as hyper or hypo thyroidism. These would be a part of what could come in 'the package' of 2-butoxyethanol poisoning.  I also wonder about neuroblastoma such as Alex had. Is neuroblastoma autoimmune?  Take a urine test in babies for early diagnosis? or hemangiomas such as happen to babies because they can also be internal:  on spleen, pancreas, liver, spine. Often baby was premature?  and of low birth weight?  Things that are indicative of this chemical's harm, as well.

If 2-butoxyethanol were involved there would be autoimmune hemolytic anemia evidenced by red blood cells that are mostly immature & in the early years, trace blood in urine.  Check 'retic' rate & track it over time.

ALD - Adrenoleukodystrophy

... the kind of thing ... that 2-butoxyethanol overexposure would cause ... Adrenoleukodystrophy (ALD) is a rare, inherited metabolic disorder that afflicts the young boy Lorenzo Odone, whose story is told in the 1993 film "Lorenzo's oil." In this disease, the fatty covering (myelin sheath) on nerve fibers in the brain is lost, and the adrenal gland degenerates, leading to progressive neurological disability and death. People with ALD accumulate high levels of saturated, very long chain fatty acids in their brain and adrenal cortex because the fatty acids are not broken down by an enzyme in the normal manner. So, when the ALD gene was discovered in 1993, it was a surprise that the corresponding protein was in fact a member of a family of transporter proteins, not an enzyme. It is still a mystery as to how the transporter affects the function the fatty acid enzyme and, for that matter, how high levels of very long chain fatty acids cause the loss of myelin on nerve fibers. More recently, all the transporters related to ALD protein have been found in the yeast Saccharomyces cerevisiae, and a mouse model for the human disease has been developed. These and other molecular biology approaches should further our understanding of ALD and hasten our progress toward effective therapies. Source In speaking with a researcher for ALD, he said that the mother must have a certain thing happening with the X chromosome. I found that this chemical exposure does cause some problems with a woman's X chromosome, so possibly a birth defect for her? Margaret e-mail Who am I?  Just an ordinary person who  looked into the harm of this chemical (& spent a lot of time doing so since June, 2002)